I recently decided to play around with defragging the index database. I tried pay for programs, but they would never defrag the database. I finally found a program called Power Defragmenter that allows single file defragging.
I defrgged the database and wow it did speed up the start time and overall performance of the program. I also defragged my library.
I don't know it will work for anyone else, but it has worked on two machines I know.