Repartitioning the hard drive to ensure Logos is on the outer edge of the drive may noticeably help performance because the outer edge of the drive is faster than the inner portion of the drive.
In my case, I have a 750GB 7200RPM drive. A quick benchmark showed the first portion ranged between 100-125MB/s. The middle portion of the drive was 75-100MB/s. And the last portion (the inner portion of the drive) was 50-75MB/s. I repartitioned my drive to 140GB for the C: drive and 555GB for the
drive.
On my PC I had made the C: partition relatively small and had placed Logos on a much larger
partition. My hard drive was almost full and when I defragged using PerfectDisk it ended up placing Logos at the end of the
drive which meant that it was at the inner portion of the drive. Logos became substantially slower due to this. So I recently repartitioned to increase the C: drive and reinstalled Logos to the C: drive. For me, Logos is currently wrapped around the page file which is also an added bonus. After this Logos seems much more responsive on my late 2009 PC.
What does this mean? Basically, if you have a lot of data stored on your hard drive Logos may be pushed further down. You can use a free defragmenting tool such as Piriform's Defraggler to determine where Logos is on your PC (Defraggler allows you to click on the boxes to show what files are in each cluster). If the Logos files are further down than the first 1/3rd of the drive, try getting them closer to the top should help performance.
Another option for users of PerfectDisk is to use the Performance or Performance-Aggressive SMARTPlacement options to move recently modified files to the top/first part of the disk. Since Logos updates and indexes somewhat regularly, it would most likely be placed where recently modified files go when defragmenting.
Hope this information is helpful.