When I start up Logos 4.0 and immediately want to work on a new passage (eg. Sunday's Gospel), it is convenient to type the reference in the homepage GO box.
There are a couple of issues with this from my perspective:
1) As mentioned elsewhere the pericope guessing on the home page seems interminably long - it is definitely interminable I can hit enter 20 times and click on GO all I like but I have to wait until the pericope guessing is finished.
2) With the current colour scheme, I forget very quickly that this has also launched an exegetical guide. A number of times, I have wondered why the passage guide is so slow, only to remember that running away behind it is also the exegetical guide.

3) I do not need 5 bibles open. I wonder if this is not overkill, especially for new users. 3 would be a good number for me and would be less taxing on my system.
When I first started, I couldn't at all work out why the ASV, a French bible and a Danish (?) bible opened. The issue of first-run preference setting is hopefully being addressed (though we have not received any indication of this to my memory).