There an annoying bug with program scaling in Logos 5. The screenshots below are taken with Program Scaling at 150%. It matters not only because of the visual annoyance, but because it causes unnecessary screen redraws at particular points, which slows things down horribly.
I believe the issue is the size of the top menu area. You can see from the screenshot below that there's a grey line between the blue title bar and the rest of the interface. That wasn't there in Logos 4, and I believe is the part of the problem. In the example below, you can see that it grows.
The problem occurs when you click on either the Home or Library buttons. That adds an orange bar that to the top of the active button. When program scaling is set to default, adding this bar doesn't cause any problems, but to make the bar fit, Logos moves the whole workspace down a few pixels to make it fit. Here's an example:

This might not seem like a big problem, but the delay caused by having to redraw the screen can take several seconds, particularly on a slow computer with a complex layout. The same problem also forces the home page to refresh once it's loaded.