Computer: Surface 3
OS: Windows 10 (Version 1703)
Browser: Chrome Version 59.0.3071.115 (Official Build) (64-bit)
I've been experiencing pretty regular problems with three-column layouts and especially with the three-column layout that has two rows in the rightmost column (e.g., 1, 1, 2 or |1|1|2|). This is the layout that I've been experimenting with most lately, so other layouts may have similar problems. I don't recall, however, experiencing these problems with the most basic one and two column layouts. They have arisen in both Chrome and Edge, as I recall.
The most common issue I've run into is that if I place one of my original-language bibles (e.g., LHB, BHS, or NA28) in the middle column (i.e., column 2) and link it to one of my lexicons (e.g., HALOT or BDAG) located in one of the side columns (i.e., column 1 or 3), then when I left-click on a word, it fails to pull up (or populate) the corresponding entry in my lexicon. Furthermore, when I right click on a word, the context menu will regularly fail to populate that selection but will open another selection aligned to the right of my cursor, the column, and/or line/verse (e.g., selecting a word, a chapter or verse number, or an entire verse). See the screenshot below as an illustration, in which I right-clicked on אנוש or אֱנ֑וֹשׁ (w/ nikkud) in Genesis 4:26, but the selection in the context menu is the surface text of verse number "26", well to right right of where I had placed my cursor. Sometimes I'll even get an odd selection at the top of the screen (e.g., in verse 22).
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I do not experience these context-menu problems with other resources such as my lexicons (e.g., HALOT) placed in the middle column. In that case, I can right-click on the word that I want to select in my lexicon, and the context-menu will populate correspondingly. That said, other complex, data-rich resources could potentially exhibit similar issues.
I've also had some occasional problems with panels failing to load in the same layout and perhaps most commonly in the middle column. I usually load resources from the command menu. I may have to experiment with this more, however.